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Bilateral, frequently symmetrical white patches that enlarge with time are the hallmark of this long-term acquired pigmentation disease, which typically indicates a substantial loss of functioning melanocytes in the epidermis and some in the hair follicles

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Monoamine Oxidase (MAO) Inhibition: Although its clinical relevance is debated, at high doses amphetamine acts as a weak competitive inhibitor of monoamine oxidase, the mitochondrial enzyme responsible for degrading free cytosolic monoamines