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In patients with MASLD and obesity, the increased activity and expression of microsomal cytochrome P450 (CYP) 2E1 and CYP4A11 was observed, with this increase showing a significant correlation with elevated levels of circulating ketone bodies and FFAs, high-density lipoprotein, triglycerides, insulin, and insulin resistance (Aljomah et al

Eloralintide is currently in Phase 3 testing and not FDA-approved yet, but early testing suggests it can help people lose an average of about 10% to 20% of body weight

They are also approved for other indications, including weight loss in adolescents (aged 12-17) and cardiovascular risk reduction in type 2 diabetics [17]