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To estimate the risk according to smoking amount in detail, current smokers were categorized into quantiles according to the cumulative amount of smoking to estimate the HR of all-cause mortality and death from all cancer, lung cancer, cardiovascular diseases by sex with never smokers as the reference

[8] In practice e-cigarette users tend to reach lower blood nicotine concentrations than smokers, particularly when the users are inexperienced [188] or using first-generation devices

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Philip Morris claims that IQOS is less toxic than cigarettes, but multiple papers in an issue of the journal Tobacco Control concluded that the companys own data does not fully support those claims