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Elevation of ROS levels results in oxidative stress in airway epithelial cells which activates an antioxidant defence mechanism known as the Keap1Nrf2 pathway to counteract the harmful effects of oxidative stress (Schieber and Chandel 2014)

Fatigue : A sense of tiredness or lethargy, related to the bodys declined energy levels after nicotine, which normally increases alertness and energy

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