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Gritstone Biotech employed Venezuelan equine encephalitis virus-based self-amplifying mRNA vector in a lipid nanoparticle called GRT-R910 encoding both the prefusion stabilized full-length SARS-CoV-2 spike and additional conserved T-cell epitopes from ORF3a, NP and membrane (Table 3)

The 3.0 mL dilution is deliberately large so each dose reads at several units or more, where U-100 syringe markings are most precise

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N-acetylcysteine (NAC) and liposomal forms show better uptake