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Moreover, counteraction of the lidocaine effect [60] (i.e., lidocaine occupied receptors on the sodium channel in its open/active (phase 0) and inactivated/refractory (phase 2) states [280]) can suggest that, as lidocaine, BPC 157 itself can have a high affinity for its receptors during both phases

Rai, V., Yadav, U., Kumar, P., Yadav, S

It would be beneficial if compound 102 can inhibit Hv1 at the same time while activating GPX4, as both lead to the reduction of ROS and neuroprotective function