Plant GPXLs, containing cysteine in their active site domain, may have dual roles, acting as glutathione peroxidase and thioredoxin peroxidase functions ( 2 O 2 and organic hydroperoxides, as well as their involvement in regulating cellular redox homeostasis by maintaining thiol/disulfide or NADPH/NADP+ ratios ( Deficiency in the activity of either GSH1 or GSH2 impairs GSH production, negatively impacting plant growth and development
Conditions such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and hepatitis have all been associated with altered glutathione metabolism
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However, self-medication or excessive treatment may increase the risk of the side effects of glutathione injection, including allergic reactions, digestive discomfort, and skin sensitivity