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Single-cell RNA sequencing studies in murine smoke models have identified an excessive influx of monocyte-derived macrophage subset population responsible for heightened inflammation and ECM remodeling, a finding that has also been validated in emphysematous COPD patients 59

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For more information on the importance of Tobacco 21, see this article from Kansas City Medicine by Bridget McCandless, MD, MBA, retiring president of the Health Forward Foundation and a past president of KCMS.

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