thioredoxin glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target Interaction of adenanthin with glutathione

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Rong S, Segal S, Anver M, Resau JH, VandeWoude GF

Activators At the transcriptional level, NFE2L2 gene is induced by several transcription factors, including the aryl hydrocarbon receptor (AhR) in response to environmental pollutants like polycyclic aromatic hydrocarbons, breast cancer susceptibility gene 1 (BRCA1) in response to xenobiotic stress, and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) in response to inflammatory stimuli