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FIGURE 9 4 Discussion GHK and its bioactive form, GHK-Cu, have been demonstrated to be safe and effective in various cellular, tissue, and animal models ( In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses ( in vivo and in vitro experimental models revealed that GHK-Cu upregulates the expression level of Occludin and ZO-1, suggesting its potential role in promoting intestinal barrier repair

Anti-neoplastic action of cimetidine/vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer

Trial registration Clinical trial number: Not applicable Consent for publication All authors read and approved the manuscript for publication Competing interests The authors declare no competing interests

Wallingford, UK: CABI (2015)