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Within the brain, densities of these receptors are extremely high in the hippocampus and are also very high in the amygdala (both areas are heavily associated with stimulus, reward, addiction and so on)

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Similarly strong inhibition was also observed for nornicotine formation in CYP2B6-overexpressing cell microsomes, with 1 and 10 M CBD exhibiting 75% and 85% inhibition, respectively, and 1 and 10 M 7-OH-CBD exhibiting 64% and 72% inhibition, respectively (Figure 3E)