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In the lipid-rich liver environment, elevated CPT expression and FAO might increase mitochondrial ROS and lead to cell death of CD4 + T cells, thus promoting tumor formation in a murine model, which could be blocked by the CPT inhibitor perhexiline (Brown et al., 2018)

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The cellular Nrf2 level is quite low in normal unstressed situations, but it substantially increases when exposed to electrophilic compounds or reactive oxygen species (ROS) (Itoh et al., 1997)