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What GHK-Cu adds to the formulation: Gene expression modulation across hundreds of genes including collagen genes (Type I, III), tissue inhibitors of metalloproteinases, anti-inflammatory mediators Collagen synthesis stimulation, specifically Type I and Type III collagen the structural proteins of skin, connective tissue, and many other tissues Anti-inflammatory signaling through investigated effects on TNF-, IL-6, and NF-B pathways Copper-peptide chemistry effects including cofactor activity for skin-relevant enzymes Skin-research and hair-research applications (the GHK-Cu literature in these areas is substantial) For the GHK-Cu deep-dive, see Copper Peptides Explained

Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO-1/NQO1 pathway

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[9], we collected some of these compounds: in brief, we defined the beneficial effects of the following: of anakinra and anti-IL-1b monoclonal antibodies (Mabs) in inhibiting the IL1-b/IL-1R1 axis