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Urinary urgency & retention (alpha-mediated effects on the urinary bladder) Piloerection Pharmacokinetics: given orally midodrine is converted the active metabolite (desglymidorine) by removal of a side group (deglycation) by enzymes present in many body tissues, including the liver

(1) Bethanechol is a direct-acting muscarinic agonist that stimulates M3 receptors on the bladder detrusor muscle to promote contraction and facilitate urination