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While glutamate is typically abundant in the standard human diet, cysteine and glycine are frequently depleted, especially during times of chronic metabolic stress, severe viral infection, or the natural aging process

After the discovery of SOD as the first line of defense against ROS ( Figure 2 Apart from the SOD and catalase system, the glutathione system, which is composed of glutathione (GSH), -glutamyl cysteine synthase (GCS), GSH synthetase, glutathione peroxidase, and glutathione reductase (GSR), also plays an important role in mediating cellular redox homeostasis

It is difficult to evaluate the effect of GSH in topical aqueous solution because of its instability

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