Some of the common behaviors in ICD are hypersexuality, compulsive buying, gambling, and punding (repetitive, purposeless behavior, often involving mechanical or compulsive tasks, like sorting, collecting, or disassembling objects) (67)
Tardito S, Oudin A, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen P, Weinstock A, Wagner A, Lindsay SL, Hock AK, Barnett SC, Ruppin E, Mrkve SH, Lund-Johansen M, Chalmers AJ, Bjerkvig R, Niclou SP, Gottlieb E
Microbial metabolites such as short-chain fatty acids (SCFAs), particularly butyrate, exert protective effects by enhancing regulatory T cell differentiation and intestinal barrier integrity, with butyrate treatment reducing lesion size in murine models (42)
This combination also disrupts human cell viability and gut microbial composition in vitro