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Pain management in patients with liver cirrhosis

Sublingual "administration" is sublingual placement followed by gastric degradation after swallowing

In both scenarios this robust HO-1 response might be an attempt to promote homeostasis, which is effective when microglia are not yet fully activated (i.e., Buffer DA & SYN DA ) but fails when glia are driven to a robust classical activation state (i.e., misfolded SYN)