l carnitine and methylcobalamin for gip comparison Frontiers Propionic Acidemia, Methylmalonic Acidemia, and

H., Adamu, H

Glutathiones main roles include: Neutralizing harmful free radicals Acting as a cofactor for several antioxidant enzymes Regenerating vitamins C and E Neutralizing free radicals produced by Phase I liver metabolism of chemical toxins, including formaldehyde, acetaminophen, benzpyrene, and many other compounds Participating in Phase I and Phase II detoxification reactions Adhering to toxins and heavy metals (including mercury) before carrying them out of the body Regulating cellular proliferation and apoptosis Participating in mitochondrial function and the maintenance of mitochondrial DNA Essentially, glutathione is crucial for shielding cells from endogenous and exogenous reactive oxygen and nitrogen species, as well as dealing directly with the causes of oxidative stress such as mercury and pollutants

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

Our findings raise the notion that reductions in key antioxidant mechanisms may be the biological risk factor for the development of konzo, particularly those mediated through pathways involving the glutathione peroxidase family