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Classification system features were compared based on completeness, clarity (coding duplication rate), mapping (fraction of candidate concepts with administrative mapping), compositional, synonyms, attributes and uncertainty, taxonomy (# of first-degree relatives per concept), meaningless identifiers, unique identifiers, definitions (fraction of concepts with definitions provided), language independence, and syntax/grammar

As such, when people use nicotine for an extended period, especially in cases where nicotine is abused, the brains chemical messengers become imbalanced, affecting several bodily functions

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National Institutes of Health, National Heart, Lung, and Blood Institute website