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Multiomics and single-cell insights reveal a lysophosphatidic acid-mediated resistant mechanism to third-generation EGFR-TKI in non-small cell lung cancer

Additionally, the expression of mRNA and protein for both 25-hydroxylases (CYP2R1 and CYP27A1), 1--hydroxylase (CYP27B1), and VDR were downregulated, but that of 24-hydroxylase (CYP24A1) was significantly upregulated in the liver of HFD-fed mice compared to those in controls (Fig