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Furthermore, these supplements may function as complementary interventions in conjunction with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), potentially enhancing therapeutic efficacy or mitigating the necessity for higher dosages (97)

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J Neurosci Res 79:509521 Aureli T, Miccheli A, Di Cocco ME, Ghirardi O, Giuliani A, Ramacci MT, Conti F (1994) Effect of acetyl-l-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the ratstudy by 13P- and 1H-NMR spectroscopy

A population-based study in 3,884 elderly men and women with depressive disorders found that those with vitamin B 12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B 12 status (98)