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Also, air pollution exposure can cause thyroid diseases, and studies have considered the effects of carbon monoxide (CO), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), ozone (O 3 ), and particulate matter 10 mg/L ( 3.4 Relationships between environmental pollution and thyroid cancer The global incidence of thyroid cancer has increased rapidly, with a rate of +1.1% per year in the last decades ( The International Agency for Research on Cancer (IARC) has classified outdoor air pollution and particulate matter (PM) in outdoor air pollution as carcinogenic to humans, and in accordance with the WHO, in 2013, particulate matter air pollution was declared as carcinogenic ( 2.5 might cause thyroid cancer is unclear

Heterogeneity was assessed quantitatively using the I2-statistics and Cochrans Q (Higgins and Thompson, 2002)

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