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In 1884, Page sold the building to Jacob and Helen Yates Walker, who continued to run it as a railroad hotel until 1915

In response, we are reducing space allocated to cigars and optimizing our assortment

This is the earliest direct biomolecular evidence of betel nut use in south-east Asia. We demonstrate that dental calculus can preserve chemical signatures of psychoactive plant use for millennia, even when conventional archaeological evidence is completely absent, added Dr Shannon Tushingham, the senior author, who is the associate curator of anthropology at the California Academy of Sciences

The study is published in the American Journal of Psychiatry.