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Introduction The recent emergence and rapid global spread of Severe Acute Respiratory Syndrome (SARS) Coronavirus 2 (SARS-CoV-2) and the resulting coronavirus disease 2019 (COVID-19) is associated with more than 12,077,210 cases and more than 550,327 deaths worldwide as of July 9, 2020 (COVID-19 Map from Johns Hopkins Coronavirus Resource Center)

As shown in Figure 1, while smoking causes a significant increase in the levels of all markers examined, these increases are much smaller, and in some cases (IL-6) even completely abolished, among exclusive e-cigarette users

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In smoking, on the contrary, oxygen breaks down the organic matter in the tobacco, releasing heat and combustion gases, water, and carbon dioxide