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Losing excess weight and cutting down accumulated body fat is not only relevant for aesthetic body shape but being overweight and obese accounts for several cardiovascular and cardiometabolic disorders such as hypertension, coronary artery disease, diabetes mellitus, etc

Retrieved 15 April 2020

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The ephrin pathway plays a crucial role in immune function and inflammatory responses and proteomics studies further support evidence of chronic inflammation, perhaps chronic infection (Milivojevic et al., 2020) and immune dysregulation (Giloteaux et al., 2023), with additional links to coagulation abnormalities and chronic infection (Nunes et al., 2022)