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A thing ." "It bleeds." "A bleeding thing, well-observed." "Not many things bleed ." "Exactly, narrows it down." "To what?" Hull stretched his arms lazily, leant back with a pensive expression on his face, sipped at his moderately alcoholic tea, and hummed with the air of the deeply contemplative and effortlessly wise
Beyond the aforementioned regulation in PH, SMURF1 is subject to extensive multi-level modulation in vascular cells: at the transcriptional level, upstream stimulatory factor 2 directly binds to its promoter region to repress transcriptional activity, while androgens/androgen receptor, retinoic acid and the inflammatory cytokine TNF- positively regulate its transcriptional expression via distinct signaling cascades (Kaneki et al
Clinical and pathological significance of cutaneous manifestations in ANCA-associated vasculitides
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