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Additional information Peer review information Nature Immunology thanks Marcus Conrad, Christian Lood and Chandra Mohan for their contribution to the peer review of this work

Luteinizing hormone stimulates testosterone production from the gonad in males, and it also stimulates estrogen production

Nonpolar solvents don't dissolve ionic or polar solutes, or only slightly dissolve them

As essential proof, we used confirmation by the exogenous application of the NO-agents given that they would mimic the NO-system corresponding to endogenous significance and effect, all as a whole, as an essential neurotransmitter evidence proof