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J Clin Oncol 32(15):65.e1965.e25 Andreotti G, Karami S, Pfeiffer RM, Hurwitz L, Liao LM, Weinstein SJ et al (2014) LINE1 methylation levels associated with increased bladder cancer risk in pre-diagnostic blood DNA among US (PLCO) and European (ATBC) cohort study participants