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There are currently more than 1.3 billion liver disease patients worldwide, and viral hepatitis, especially hepatitis B, is still the main cause of chronic liver disease and end-stage liver disease

Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110, and the following autophagy and drug resistance regulation

Furthermore, ROS mediates the intrinsic apoptosis by promoting the release of proapoptotic factor cytochromec from mitochondria to form apoptosome with apoptotic protease activating factor 1 (APAF1) and caspase9 [151]

To assess mitochondrial morphology and functional states MitoTracker Green FM Dye, MitoTracker Red FM Dye, and TMRM, (all from Thermo Fisher Scientific) were used according to the manufacturer instructions