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The intranasal GHK-Cu treatment was found to delay cognitive impairment, reduce amyloid plaques, and lower inflammation levels in the frontal cortex and hippocampus .37 Randomized controlled trials in human patients are needed to confirm the benefit of GHK-Cu for cognitive decline and Alzheimers disease as well as to evaluate safe and effective human dosing (the human dose equivalent of 15mg/kg in mice would be ~1.2mg/kg, though data on this or any other dosing nasally in humans is not currently available), but preliminary animal trials are promising
The materials reviewed for this article did not provide a complete NAD+-specific contraindication list, so this article does not identify particular conditions as automatic qualifications or exclusions - that determination belongs to the evaluating provider
An Abbreviated New Drug Application (ANDA) for a generic nasal spray must demonstrate that the generic product is bioequivalent to the Reference Listed Drug (RLD)
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