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Moreover, kynurenine competes with other amino acids, such as methionine and leucine, that are transported by Slc7a5 to T cells, thereby impairing T cell-mediated immune responses [284]

Cell 140:883899

& Mithen, R

Genetic polymorphisms As mentioned before, the high inter- and intrapatient variability of Tac PK poses a problem for clinical management, especially when defining the starting dose after transplantation as well as dose adjustment of ongoing therapy