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In specific embodiments, osmolarity/osmolality of the present formulations or compositions is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of sodium salts) or the use of tonicity agents which renders the formulations or compositions endolymph-compatible and/or perilymph compatible (i.e

NTS were placed in 96-well flat-bottom plates (Nunclon, Roskilde, Denmark) and incubated with M199 supplemented with 20 mM HEPES or 7.5% sodium bicarbonate and increasing concentrations of heat inactivated fetal bovine serum (iFBS), 515%, 37 C in 5% CO 2 in air