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This correlation was only found between the number of cigarettes consumed per day and cotinine concentrations in the FF ( r = 0.27

Doseresponse relationships between smoking and Chronic Obstructive Pulmonary Disease as related to smoking duration (years of smoking), smoking intensity (daily cigarettes), lifetime tobacco consumption (pack-years), age at smoking initiation, and years of abstinence

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The increased inflammatory profile of MoAM compared to ResAM was further substantiated by an increased expression of several pro-inflammatory chemokines ( Ccl2, Ccl7, Ccl3, Ccl4, Ccl9, Ccl17, Cxcl2, Cxcl3, Cxcl16 ) ( Figures 5C, G )