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Light smoking and even second-hand smoke suffuses your veins with toxins that can lead to life-threatening vascular conditions, such as: Atherosclerosis clogged or stiffened arteries that slow down healthy blood flow Coronary heart disease arteries in the heart become blocked or narrowed Stroke loss of brain function due to interrupted blood flow Abdominal aortic aneurysm an enlargement in the main blood vessel in the abdomen that has the potential to rupture Smoking-related blood vessel damage can also lead to peripheral artery disease (PAD), which makes the circulation in your legs and arms so sluggish that you may develop gangrene, and need to have a limb amputated