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17 With immune-mediated disorders, TPE can alter the T-helper type 1 and T-helper type 2 cell ratio by increasing the predominance ratio from Th-2 to Th-1, thereby boosting humoral immune response and modulating cellular immunity

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"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044