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Chem Senses 46:bjab046

In order to investigate the combined effect of exposure to PM10 and smoking, women were divided into 4 groups: low exposure to PM10 and non-exposed to smoke (LowPM-nSM, the reference condition), high exposure to PM10 and non-exposed to smoke (HighPM-nSM), low exposure to PM10 and exposed to smoke (LowPM-SM), and high exposure to PM10 and exposed to smoke (HighPM-SM)

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This results in a chronic inflammatory microenvironment, known to affect key carcinogenic processes such as cell growth, proliferation and migration, apoptosis and differentiation to tumour-like phenotypes [105, 113, 117119]