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This work also has other important strengths over previous studies including the sample size, length of intervention, multiple toxicant exposure measures and control conditions. The question of whether an e-cigarettes nicotine delivery profile is predictive of its ability to reduce harm and promote behavior change among smokers remains highly relevant to policymakers, public health advocates, health care providers and smoking populations

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Peter van den Driest, a local spokesperson for Philip Morris, had declared in 2018 that these machines did not measure actual exposure, but were "intended to make brands comparable when cigarettes are smoked identically" [2], which strongly resembles a pirouette since the nicotine, tar and CO contents reported on the packets are supposed to come from this measurement and inform smokers

Others may have difficulty breathing, cough up black mucus and experience chest tightness