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doi:10.1176/appi.ps.201800321 pmid:30554562 Mello NK, Newman JL (2011) Discriminative and reinforcing stimulus effects of nicotine, cocaine, and cocaine + nicotine combinations in rhesus monkeys

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A report by the National Academy of Sciences, Engineering, and Medicine (NASEM) concluded, "There is strong evidence that the full replacement of combustible tobacco products with e-cigarettes reduces the exposure of smokers to a wide range of toxic and carcinogenic substances from combustible tobacco products