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However, if you do experience any of the following side effects, then you should call your doctor immediately: Signs of an allergic reaction including breathing problems, hives or swelling in the face, tongue or throat Symptoms of very high blood pressure including severe headaches, chest pain, shortness of breath, uneven heartbeats, seizures, blurred vision, buzzing in the ears, confusion or anxiety Signs of stomach or intestinal bleeding including stomach pain, abdominal pain, vomit that looks like coffee grounds or black or tarry stools Symptoms of infection including fever or a persistent sore throat Changes to your mood or mental state such as depression, agitation, or mood swings Muscle cramps, weakness or pain, or bone pain Vision problems including blurred vision Slow wound healing Easier bruising or bleeding Irregular heartbeats Swelling in the hands, ankles or feet or puffy face Seizures Menstrual changes [6] Side Effects of Extended Use As an immunosuppressant medication, prednisone works by reducing the effectiveness of the bodys immune system