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Padayatty S, Riordan H, Hewitt S, Katz A, Hoffer L, Levine M

Nature 619 , 151159 (2023)

In adipocytes, this produces a 1.2 to 1.6-fold increase in intracellular NAD+ Lipogenesis suppression : Increased NAD+ availability in adipocytes suppresses lipogenic pathways, reducing fat synthesis and storage SAM/SAH ratio modulation : Inhibiting NNMT's consumption of SAM alters the SAM/S-adenosylhomocysteine (SAH) ratio, which may affect broader methylation dynamics Muscle effects : In aged mice, NNMT inhibition improved muscle proteome and metabolome profiles through mechanisms distinct from exercise, suggesting direct effects on muscle cell biology How 5-Amino-1MQ Differs from NAD+ Precursors# These approaches are mechanistically complementary, though their combination has not been studied

Mol Cell Endocrinol 347(12):8089 Bikle DD (2014) Vitamin D metabolism, mechanism of action, and clinical applications