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Now this isnt strictly necessary, but I like to replace the wadding with fresh wadding when I restore my lighters

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This revealed that CR hi tumors were significantly enriched for cell-cycleregulating genes (Figure 9A), with core enrichment of regulators of G 1 /S transition (e.g., CDK6 , CDC6 , CCNE1 ) and early S-phase progression (e.g., DBF4 ), when nucleotide pool imbalances can induce cell-cycle arrest