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Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation

Frequency of cognitive impairment defined as TICS31 were 21.9% at year one, 15.2% at year two, and 11.5% at year three

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We argue that viewing MS through the lens of an early onset, slowly progressive cytodegeneration of white and gray matter elements, convolved with a variable overlay of adaptive autoimmunity, could readily explain the entire disease spectrum, and aligns well with emerging new evidence