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Bevilacqua, Arturo, and Mariano Bizzarri

The proposed mechanism is indirect modulation of the NO pathway rather than direct receptor agonism, though the precise molecular binding event has not been definitively characterized in peer-reviewed work

Retevmo is specifically indicated for advanced or metastatic medullary thyroid cancer with a RET mutation, advanced or metastatic thyroid cancer with a RET gene fusion untreatable with radioactive iodine therapy, and locally advanced or metastatic solid tumors with a RET gene fusion that have progressed after prior systemic treatment or have no treatment options, according to the publication