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Carcinogenic components of tobacco smoke promote lung cancer by causing DNA damage that can lead to mutations through known mechanisms, but what the initial consequences of smoking are for healthy lung cells is poorly understood

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For instance, much of the epidemiological research surrounding this comorbidity has found no effect or worsened cognition within chronic smokers with SZ (1 has been included below to illustrate the variety of study methodologies examining the pro-cognitive effects of smoking and how each study accounted for the duration since last cigarette

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