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This is because they are agonistic in the skin, but are not agonistic when bound to ER, thereby avoiding hyperplasia of the breast and endometrium and venous thromboembolism

The elegant experiments showing that MiADMSA reverses resistance suggest a causal role, but it remains possible that the metallomic alterations are a downstream effector of a more fundamental, metal-independent resistance program, such as a stemness transcription factor network

Iron is necessary for the production of red blood cells and for transporting oxygen throughout the body, including to the reproductive organs

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