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Bycroft C, Freeman C, Petkova D, et al

Historians believe that the small pox virus first arrived in the New World around Christmas, 1518

The Connecticut River Valley Tobacco cultivation in the Connecticut River Valley stretches as far as south as East Haddam, Connecticut, and shoots northward along the Connecticut River through Massachusetts and New Hampshire and into the lower portion of Vermont

Globally accepted methods from the World Health Organizations Tobacco Laboratory Network (TobLabNet), the Centers for Disease Control and Prevention (CDC), and the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) were used