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High IGF-1 levels have been linked to increased risk for gastrointestinal, prostate, ovarian and breast cancers (18, 19)

The effect of hyperoside on the functional recovery of the ischemic/reperfused isolated rat heart: potential involvement of the extracellular signal-regulated kinase 1/2 signaling pathway

and decaffeinated instant contains 5 mg of caffeine per cup (Morgan et al., 2013)

Afr J Biotechnol 10:634863 Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A (2003) Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK