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Despite a strong theoretical rationale, and a number of supportive clinical trials, a Cochrane review of published data, based on nine randomized controlled trials with 434 patients in different stages of ALD, did not demonstrate any significant benefit of SAMe on total mortality, liver related mortality, complications or liver transplantation in patients with ALD

They are commonly prescribed for people with pernicious anaemia, malabsorption conditions, certain digestive disorders, or those who cannot maintain healthy levels through diet or oral supplements alone

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