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The adverse effects of intravenous glutathione speculatively arise from the direct delivery of huge amounts of the molecule in the blood circulation

crassawith 12.5 M STS or vehicle, as indicated, for the indicated times

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However, only poly(I:C) treatment results in elevated IL-8 transcript levels and increased nitric oxide production ( TLR3 expression is significantly upregulated following stimulation with recombinant TNF (rTNF) but is downregulated after treatment with poly(I:C) and peptidoglycan (PGN)