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Amorim AMB, Piochi LF, Gaspar AT, Preto AJ, Rosario-Ferreira N, Moreira IS

Fed-state administration elevates insulin and mTOR, which directly antagonize autophagy initiation and reduce peptide uptake by 4060%

The redox properties of NADs regulate the direction of hundreds of cellular biosynthetic pathways varying from amino acid, lipid and nucleotide synthesis to folate cycle, detoxification reactions of drugs and reactive oxygen species 57

The concept of enhanced lactate production was first described a century ago by the Warburg effect, which revealed that tumor cells rely on anaerobic glycolysis even in the presence of oxygen, providing them with numerous advantages